Mutations that affects a single nucleotide usually by substituting
The difference of point mutation and frameshift the main two ways of gene mutations.. Two types of frame shift mutations both insertions and deletions change the sequence. Example: sickle cell disease is caused by a single point mutation. Deletion frameshift to get rid of nucleotide and base sequence.. Addition Frameshift adding a nucleotide to the base sequence. FRame shift mutation that shifts the reading frame of the genetic message